The Clore Laboratory
University of 天美传媒官方网站
Hunter Street
天美传媒官方网站
MK18 1EG, UK
Tel (office): 听+44 (0)1280 820368
Tel (lab): 听+44 (0)1280 820323
Biography
Ma艂gorzata gained an MA in Biology (2006) at the University of Szczecin in Poland, where she investigated differences between mitochondrial genomes amongst several lines of triticale (X Triticosecale Wittmack).听During her MA she has also gained research experience in the Max Planck Institute of Molecular Plant Physiology in Germany where she contributed to the research project:听鈥欌橧dentification of novel nodule-induced transporter genes in the model legume,听L japonicus鈥.
In 2006 Ma艂gorzata joined the 天美传媒官方网站 Institute for Translational Medicine at 天美传媒官方网站 where she obtained an MSc in Biomedical Science (2009). Her thesis was on 鈥欌橳he effect of knocking out preprodynorphin gene on 脽-cell morphology鈥欌.听She was also awarded a DPhil in Biomedical Science (2014). Her PhD thesis was entitled 鈥欌橳he impact of maternal over-nutrition and maternal obesity on the development of obesity in the offspring鈥欌.
Since 2014 Ma艂gorzata has been working as a Research Fellow at the BITM听towards discovery of novel therapeutic targets (e.g. G-protein-coupled receptors, cannabinoid receptors) for the treatment of obesity and type 2 diabetes and understanding of the molecular mechanisms of these diseases.听 Ma艂gorzata utilises a range of听in vivo听补苍诲听in vitro听methods and specialises especially in molecular biology techniques, particularly gene expression.听She has also experience in supervision of students conducting lab-based scientific projects and is a Personal Tutor for medical students.
Key Research Interests
Adipose tissue dysfunction in obesity and its consequences
Developmental origins of metabolic syndrome
Gut microbiota dysbiosis and its link with metabolic diseases
Publications (last 5 years):
Muredda L,听碍臋辫肠锄测艅蝉办补 MA, Zaibi MS, Alomar SY, Trayhurn P (2017). IL-1尾 and TNF伪 inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.听Arch Physiol Biochem. 24:1-12.
碍臋辫肠锄测艅蝉办补听MA,听Zaibi听MS, Alomar听SY and Trayhurn听P (2016). PCR arrays indicate that the expression of extracellular matrix and cell adhesion genes in human adipocytes is regulated by IL-1尾 (interleukin-1尾).听Arch Physiol Biochem.听123(1): 61-67.听DOI:听
Azevedo CM,听Watterson KR,听Wargent ET,听Hansen SV,听Hudson BD,听碍臋辫肠锄测艅蝉办补 MA,听Dunlop J,听Shimpukade B,听Christiansen E,听Milligan G,听Stocker CJ,听Ulven T听(2016). Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity.听J Med Chem. 59(19):8868-8878.听.
Alomar SY,听Gentili A,听Zaibi MS,听碍臋辫肠锄测艅蝉办补 MA,听Trayhurn P听(2016). IL-1尾 (interleukin-1尾) stimulates the production and release of multiple cytokines and chemokines by human preadipocytes.听Arch Physiol Biochem.听122(3):117-22.听.
Harzallah A, Hammami M,听碍臋辫肠锄测艅蝉办补听MA,听Hislop DC, Arch JR, Cawthorne MA, Zaibi MS (2016). Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model.听Arch Physiol Biochem听122(2), 75-87.听.
Alomar SY, Zaibi MS,听碍臋辫肠锄测艅蝉办补 MA, Gentili A, Alkhuriji A, Mansour L, Dar JA, Trayhurn P (2015). PCR array and protein array studies demonstrate that IL-1尾 (interleukin-1尾) stimulates the expression and secretion of multiple cytokines and chemokines in human adipocytes.听Arch Physiol Biochem听121(5), 187-93.听.
碍臋辫肠锄测艅蝉办补 MA,听Wargent ET, Cawthorne MA, Arch JRS, O鈥橠owd JF, Stocker CJ (2013). Circulating levels of the cytokines IL10, IFNg and resistin in an obese mouse model of developmental programming.听JDOHaD听4(6):491-498.听.
Osman, OS, Selway JL,听碍臋辫肠锄测艅蝉办补 MA,听Stocker CJ, O鈥橠owd JF, Cawthorne MA, Arch JRS, Jassim S, Langlands K (2013). A novel automated image analysis method for accurate adipocyte quantification.听Adipocyte听2(3): 1.听
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